GPCRs: Adenosine Receptors - MMS

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GPCRs - Adenosine Receptors

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G protein-coupled receptors (GPCRs) represent the largest family of signal-transducing molecules known. They convey signals for light and many extracellular regulatory molecules. GPCRs have been found to be dysfunctional/dysregulated in a growing number of human diseases and have been estimated to be the targets of more than 40% of the drugs used in clinical medicine today. The crystal structures of several GPCRs  support both homology modeling studies and structure-based drug design approaches. Our scientific efforts are directed on adenosine receptors, We will place the greatest emphasis on an iterative, bi-directional approach in which models are used to generate hypotheses that are tested by experimentation and the experimental findings are, in turn, used to refine the model. The success of this approach is due to the synergistic interaction between theory and experiment.

Collaborators:

Giampiero Spalluto's group
Vittoria Colotta's group
Kenneth A. Jacobson's group
Karl N. Klotz's group
Fernanda Borges's group
Eugenio Uriarte's group

Pubblications:

 
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