2009-2012 - MMS

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194. Floris M, Sabbadin D, Medda R, Bulfone A, Moro S. "Adenosiland: walking through adenosine receptors landscape." Eur J Med Chem. 58, 248-257 (2012).

193. Federico S, Ciancetta A, Sabbadin D, Paoletta S, Pastorin G, Cacciari B, Klotz KN, Moro S, Spalluto G. "Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists." J Med Chem. 55, 9654-9668 (2012)

192. Furlanetto V, Zagotto G, Pasquale R, Moro S, Gatto B. "Ellagic Acid and Polyhydroxylated Urolithins Are Potent Catalytic Inhibitors of Human Topoisomerase II: An in Vitro Study."J Agric Food Chem. 60, 9162-9170 (2012).

191.  Cozza G, Pinna LA, Moro S. "Protein kinase CK2 inhibitors: a patent review."Expert Opin Ther Pat. 22, 1081-1097

190. Colotta V, Lenzi O, Catarzi D, Varano F, Squarcialupi L, Costagli C, Galli A, Ghelardini C, Pugliese AM, Maraula G, Coppi E, Pellegrini-Giampietro DE, Pedata F, Sabbadin D, Moro S."3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: molecular modeling and pharmacological studies." Eur J Med Chem. 54, 470-482 (2012)

189.  Gaspar A, Reis J, Kachler S, Paoletta S, Uriarte E, Klotz KN, Moro S, Borges F. "Discovery of novel A(3) adenosine receptor ligands based on chromone scaffold." Biochem Pharmacol. 84, 21-29 (2012)

188. Kozma E, Kumar TS, Federico S, Phan K, Balasubramanian R, Gao ZG, Paoletta S, Moro S, Spalluto G, Jacobson KA. "Novel fluorescent antagonist as a molecular probe in A(3) adenosine receptor binding assays using flow cytometry." Biochem Pharmacol. 83, 1552-1561 (2012)

187. Viola G, Bortolozzi R, Hamel E, Moro S, Brun P, Castagliuolo I, Ferlin MG, Basso G. "MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells." Biochem Pharmacol. 83, 16-26 (2012)

186. Cheong SL, Federico S, Venkatesan G, Mandel AL, Shao YM, Moro S, Spalluto G, Pastorin G. "The A(3) adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry, and in silico approaches." Med Res Rev. (2011) in press

185. Girolami A, Scarparo P, Bonamigo E, Santarossa L, Cristiani A, Moro S, Lombardi AM. "A cluster of factor XI-deficient patients due to a new mutation (Ile 436 Lys) in northeastern Italy*" Eur J Haematol. 88, 229-236 (2012)

184. Bertini S, Asso V, Ghilardi E, Granchi C, Manera C, Minutolo F, Saccomanni G, Bortolato A, Mason J, Moro S, Macchia M. "Carbazole-containing arylcarboxamides as BACE1 inhibitors." Bioorg Med Chem Lett. 21, 6657-6661 (2011).

183. Cozza G, Gianoncelli A, Bonvini P, Zorzi E, Pasquale R, Rosolen A, Pinna LA, Meggio F, Zagotto G, Moro S. "Urolithin as a Converging Scaffold Linking Ellagic acid and Coumarin Analogues: Design of Potent Protein Kinase CK2 Inhibitors." ChemMedChem 6, 2273-2286 (2011)

182. Inui M, Manfrin A, Mamidi A, Martello G, Morsut L, Soligo S, Enzo E, Moro S, Polo S, Dupont S, Cordenonsi M, Piccolo S. "USP15 is a deubiquitylating enzyme for receptor-activated SMADs." Nat Cell Biol. 13, 1368-1375 (2011).

181. Pendin D, Tosetto J, Moss TJ, Andreazza C, Moro S, McNew JA, Daga A. "GTP-dependent packing of a three-helix bundle is required for atlastin-mediated fusion."Proc Natl Acad Sci U S A. 108, 16283-16288 (2011).

180. Cheong SL, Dolzhenko AV, Paoletta S, Lee EP, Kachler S, Federico S, Klotz KN, Dolzhenko AV, Spalluto G, Moro S, Pastorin G. "Does the combination of optimal substitutions at the C²-, N^(5)- and N^(8)-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human Av(3) adenosine receptors?" Bioorg Med Chem. 19, 6120-6134 (2011)

179. Quintieri L, Palatini P, Moro S, Floreani M. "Inhibition of cytochrome P450 2C8-mediated drug metabolism by the flavonoid diosmetin." Drug Metab Pharmacokinet. (2011) in press

178. Cozza G, Meggio F, Moro S. "The Dark Side of Protein Kinase CK2 Inhibition." Curr Med Chem. 18, 2867-2884 (2011)  

177. Cristiani A, Brisotto N, Cedrati FC, Floris M, Scapozza L, Moro S. "ClickMD: an intuitive web-oriented molecular dynamics platform." Future Med Chem. 3, 923-931 (2011)

176. Floris M, Masciocchi J, Fanton M, Moro S. "Swimming into peptidomimetic chemical space using pepMMsMIMIC." Nucl. Acids Res. 39, 261-269 (2011)

175. Cristiani A, Costa G, Cozza G, Meggio F, Scapozza L, Moro S. "The Role of the N-Terminal Domain in the Regulation of the "Constitutively Active" Conformation of Protein Kinase CK2?: Insight from a Molecular Dynamics Investigation." ChemMedChem. 7, 1207-1216 (2011)

174. Bacilieri M, Naggi A, Ceol M, Schleicher E, Tosetto E, Comoli M, Torri G, Moro S, Palumbo M, Gambaro G. "Inhibitory effects of glycosaminoglycans on basal and stimulated transforming growth factor-beta1 expression in mesangial cells: biochemical and structural considerations." Glycobiology 21, 1029-1037 (2011)

173. Poli D, Catarzi D, Colotta V, Varano F, Filacchioni G, Daniele S, Trincavelli L, Martini C, Paoletta S, Moro S. "The Identification of the 2-Phenylphthalazin-1(2H)-one Scaffold as a New Decorable Core Skeleton for the Design of Potent and Selective Human A(3) Adenosine Receptor Antagonists." J Med Chem. 54, 2102-2013 (2011)

172. Federico S, Paoletta S, Cheong SL, Pastorin G, Cacciari B, Stragliotto S, Klotz KN, Siegel J, Gao ZG, Jacobson KA, Moro S, Spalluto G. "Synthesis and Biological Evaluation of a New Series of 1,2,4-Triazolo[1,5-a]-1,3,5-triazines as Human A(2A) Adenosine Receptor Antagonists with Improved Water Solubility." J Med Chem. 54, 877–889 (2011)  

171. Michielan L, Pireddu L, Floris M, Moro S. "Support Vector Machine (SVM) as Alternative Tool to Assign Acute Aquatic Toxicity Warning Labels to Chemicals." Mol Info. 1-2, 51-64 (2010)

170. Marino SM, Fogal S, Bisaglia M, Moro S, Scartabelli G, Gioia LD, Spada A, Monzani E, Casella L, Mammi S, Bubacco L. "Investigation of S. antibioticus Tyrosinase reactivity toward Chlorophenols." Arch Biochem Biophys. 505, 67-74 (2010).

169. Samorì C, Beretta GL, Varchi G, Guerrini A, Di Micco S, Basili S, Bifulco G, Riccio R, Moro S, Bombardelli E, Zunino F, Fontana G. "Structure-activity relationship study of 16 a-thiocamptothecins: an integrated in vitro and in silico approach." ChemMedChem. 5, 2006-2015 (2010).

168. Paoletta S, Federico S, Spalluto G, Moro S. "Receptor-driven identification of novel human A(3) adenosine receptor antagonists as potential therapeutic agents." Methods Enzymol. 485, 225-244 (2010).

167. Bertini S, Ghilardi E, Asso V, Granchi C, Minutolo F, Pineschi M, Di Bussolo V, Bortolato A, Moro S, Saba A, Macchia M. "BACE1 inhibitory activities of enantiomerically pure, variously substituted N-(3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropyl) arylsulfonamides." Bioorg Med Chem. 18, 7991-7996 (2010).

166. Quintieri L, Bortolozzo S, Stragliotto S, Moro S, Pavanetto M, Nassi A, Palatini P, Floreani M. "Flavonoids diosmetin and hesperetin are potent inhibitors of cytochrome P450 2C9-mediated drug metabolism in vitro." Drug Metab Pharmacokinet.  25, 466-476 (2010).

165. Michielan L, Moro S. "Pharmaceutical perspectives of nonlinear QSAR strategies." J Chem Inf Model. 50, 961-978 (2010).

164. Gianoncelli A, Basili S, Scalabrin M, Sosic A, Moro S, Zagotto G, Palumbo M, Gresh N, Gatto B. "Rational design, synthesis, and DNA binding properties of novel sequence-selective peptidyl congeners of ametantrone." ChemMedChem. 5, 1080-1091 (2010).

163. Cheong SL, Dolzhenko A, Kachler S, Paoletta S, Federico S, Cacciari B, Dolzhenko A, Klotz KN, Moro S, Spalluto G, Pastorin G. "The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition." J Med Chem. 53, 3361-3375 (2010).

162. Pastorin G, Federico S, Paoletta S, Corradino M, Cateni F, Cacciari B, Klotz KN, Gao ZG, Jacobson KA, Spalluto G, Moro S. "Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process." Bioorg Med Chem. 18, 2524-2536 (2010).

161. Cozza G, Bortolato A, Moro S. "How druggable is protein kinase CK2?" Med Res Rev. 30, 419-462 (2010)

160. Moro S, Morizzo E, Jacobson KA. " Molecular modeling and re-engineering of A3 adenosine receptors" in A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics. Springer (2009) - ISBN: 978-90-481-3143-3.

159. Morizzo E, Federico S F, Spalluto G, Moro S. "Human A3 Adenosine Receptor as Versatile G Protein-Coupled Receptor Example to Validate the Receptor Homology Modeling Technology." Curr Pharm Des. 15, 4069-4084 (2009)

158. Moro S. "In silico approaches in G protein-coupled receptors (GPCRs) drug discovery: quo vadis?" Curr Pharm Des. 15, 3992-3993(2009)

157. Michielan L, Feferico S, Terfloth L, Hristozov D, Cacciari B, Klotz KN, Spalluto G, Gasteiger J, Moro S. "Exploring Potency and Selectivity Receptor Antagonist Profiles Using a Multilabel Classification Approach: The Human Adenosine Receptors as a Key Study." J Chem Inf Model. 49, 2820-2836 (2009)

156. Michielan L, Terfloth L, Gasteiger J, Moro S. "Comparison of Multilabel and Single-Label Classification Applied to the Prediction of the Isoform Specificity of Cytochrome P450 Substrates." J Chem Inf Model. (2009) in press

155. Lenzi O, Colotta V, Catarzi D, Varano F, Poli D, Filacchioni G, Varani K, Vincenzi F, Borea PA, Paoletta S, Morizzo E, Moro S. "2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a New Scaffold To Obtain Potent and Selective Human A(3) Adenosine Receptor Antagonists: New Insights into the Receptor-Antagonist Recognition." J Med Chem. 52, 7640-7652 (2009)

154. Cozza G, Bortolato A, Menta E, Cavalletti E, Spinelli S, Moro S. "ATP Non-Competitive Ser/Thr Kinase Inhibitors as Potential Anticancer Agents." Anti-Cancer Agents in Med Chem 9, 778-786 (2009)

153. Zonta N, Cozza G, Gianoncelli A, Korb O, Exner TE, Meggio M, Zagotto G, Moro S. "Scouting Novel Protein Kinase A (PKA) Inhibitors by Using a Consensus Docking-Based Virtual Screening Approach." Lett Drug Design Discov 6, 327-336 (2009)  

152. Michielan L, Bolcato C, Federico S, Cacciari B, Bacilieri M, Klotz KN, Kachler S, Pastorin G, Cardin R, Sperduti A, Spalluto G, Moro S. "Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites." Bioorg Med Chem 17, 5259-5267 (2009)

151.  Lebska M, Szczegielniak J, Dobrowolska G, Cozza G, Moro S, Muszyn'ska G. "A novel splicing variant encoding putative catalytic alpha subunit, of maize protein kinase CK2." Physiol Plant. 136, 251-263 (2009)

150. Cozza G, Mazzorana M, Papinutto E, Bain J, Elliott M, Di Maira G, Gianoncelli A, Pagano MA, Sarno S, Ruzzene M, Battistutta R, Meggio F, Moro S, Zagotto G, Pinna LA. "Quinalizarin as a potent, selective and cell permeable inhibitor of protein kinase CK2." Biochem J. 421, 387-395 (2009)

149. Samori C, Guerrini A, Varchi G, Fontana G, Bombardelli E, Tinelli S, Beretta GL, Basili S, Moro S, Zunino F, Battaglia A . "Semisynthesis, Biological Activity, and Molecular Modeling Studies of C-Ring-Modified Camptothecins" J Med Chem 52, 1029-1039 (2009)

148. Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, Martello G, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S, Modena N, Argenton F, Newfeld SJ, Piccolo S. "FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination." Cell 136, 123-135 (2009)

147. Colotta V, Lenzi O, Catarzi D, Varano F, Filacchioni G, Martini C, Trincavelli L, Ciampi O, Pugliese AM, Traini C, Pedata F, Morizzo E, Moro S. "Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies." J Med Chem. 23, 2407-2419 (2009)

146. Basili S, Moro S. "Novel camptothecin derivatives as topoisomerase I inhibitors." Expert Opinion on Therapeutics Patents 19, 555-574 (2009)

145. Richter SN, Menegazzo I, Nadai M, Moro S, Palumbo M "Reactivity of clerocidin towards adenine: implications for base-modulated DNA damage." Org Biomol Chem 7, 976-985 (2009).

144. Masciocchi J,  Frau G,  Fanton M, Floris M, Sturlese M, Palla P, Cedrati F, Rodriguez-Tomé P, Moro S. “MMsINC: a  large-scale chemoinformatics database.” Nucleic Acids Res. 37, 284-290 (2009)

 
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