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MMS unit will provide its competencies in discovering and optimizing novel kinase inhibitors. In this project we have identified two serine-threonine kinases, the glycogen synthase kinase 3-b ( GSK3β) and casein kinase 1 (CK1), as potential neuroinflammatory drug targets due to their strong association with the TNF-dependent intracellular signalling. In principle, the silencing of the phosphorylation activity of both kinases might be used to abolish or drastically reduce the downstream effects of the inflammatory signalling promoted by TNF. Therefore two main objectives are considered in this part of the project: |
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Giorgio Cozza - biochemistry unit |
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